Managing Side Effects of Thiamine Supplementation: The Paradoxical Reaction

Some individuals experience negative reactions and the worsening of symptoms when they begin thiamine repletion therapies using the more biologically available formulations like thiamine tetrahydrofurfuryl disulfide (TTFD). Dr. Derrick Lonsdale calls these "paradoxical reactions".

In this video, I examine the biochemistry beyond these reactions and provide some hypotheses regarding why they happen and how to mitigate them.

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