What constitutes a CD4+ T-cell epitope? Our understanding of HLA class-II presented antigens
Автор: Unravelling T Cell Recognition
Загружено: 2025-12-08
Просмотров: 37
In this webinar, Dr Bruce McLachlan (Cardiff University) explores a central question in immunology: what truly defines a CD4⁺ T-cell epitope?
He provides an overview of the current state of HLA class-II structural understanding and examines how well we have experimentally characterised the diversity of the HLA class-II system.
Key topics covered include:
• Structural descriptors of HLA class-II presented antigens
• Recognition of these antigens by CD4⁺ T-cell derived TCRs
• Machine learning approaches for predicting peptide–HLA class-II complex structures
• How limited experimental training data impacts predictive accuracy
• How improved molecular insight can help tune CD4⁺ T-cell immunity—particularly for vaccination
About the speaker:
Dr McLachlan is a structural and cellular immunologist with research spanning NK-cell, CD8⁺ T-cell, B-cell, and CD4⁺ T-cell biology. After his PhD at Cardiff (2016), he worked in Prof Jamie Rossjohn’s lab at Monash University studying NK-cell receptors, before returning to Cardiff to examine CD4⁺ T-cell responses to SARS-CoV-2 variants. Supported by Health and Care Research Wales, his current work focuses on enhancing CD4⁺ T-cell recognition of tumour antigens to build foundations for equitable, “off-the-shelf” cancer immunotherapies.
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