肿瘤标志物AFP有何临床意义 王瑞芹 山西省肿瘤医院

肿瘤标志物AFP有何临床意义 王瑞芹 山西省肿瘤医院
AFP(甲胎蛋白）：在胎儿时期存在，主要由正常胚胎肝脏合成，妊娠6周开始合成，13周达最高水平，出生后下降，产后1年血清中AFP降至正常。正常情况下主要在胚胎组织中存在，出生后即迅速消失，如果重现于成人血清中则提示肝细胞癌或生殖腺胚胎癌，此外妊娠、肝病活动期、继发性肝癌和消化道癌证的少数也能测得AFP是最早发现的肿瘤标志物。

Clinical significance of tumor marker AFP
AFP (alpha fetoprotein): it exists in the fetal period, It is mainly synthesized by normal fetal liver, Synthesis begins at 6 weeks of gestation, The highest level was reached in 13 weeks, Decline after birth, AFP in serum decreased to normal one year after delivery. Under normal circumstances, it mainly exists in embryonic tissues, It disappears rapidly after birth, If it reappears in the adult serum, it indicates HCC or gonadoembryonic carcinoma, In addition, AFP can also be detected in a few cases of pregnancy, active stage of liver disease, secondary liver cancer and gastrointestinal cancer.