New Obesity Trial Results Change Everything! Inside the data with Fractyl Health CEO

What happens after GLP-1s?

In this episode of The Downsized, Christopher Durham sits down with Harith Rajagopalan, MD, PhD, cardiologist and CEO of Fractyl Health, to break down new clinical trial results that could reshape how we think about obesity treatment.

The data tackles one of the biggest unanswered questions in obesity care today:
👉 What do you do when you stop a GLP-1 and don’t want the weight to come back?

Harith explains Fractyl’s investigational, non-surgical procedure designed to target the root cause of obesity in the gut, not just manage symptoms. In real-world and blinded clinical studies, patients who stopped GLP-1 therapy regained far less weight than expected, with some continuing to lose weight—without ongoing medication.

We cover:
New trial results focused on preventing weight regain after GLP-1s
Why obesity and type 2 diabetes may start in the duodenum
How this outpatient endoscopic procedure works
What the data shows on weight durability and blood sugar
How this approach compares to lifelong medications and bariatric surgery
What FDA breakthrough device designation could mean for timing and access
Learn more about Fractyl Health and their research here:
👉 https://www.fractylhealth.com
+++++++++++++++++++++++++++++++++++++++
Start your weight loss journey today! We use Mochi Health: https://app.joinmochi.com/eligibility...
Use Laraine’s code for $40 off: QIYGO8.

Me Again Iphone GLP-1 App: https://apps.apple.com/us/app/meagain...

Get your Hume BodyPod today and use our exclusive Downsized code for an extra 20% off on top of the sitewide sale—up to 50% total savings! 👉 Use our Code: THEDOWNSIZED Link to purchase: https://humehealth.com//discount/THED...

To receive 20% off your Purchase of Biocare Protein Bars or Shakes, visit https://biocarenutrition.com/DOWNSIZED and enter the discount code DOWNSIZED

AMAZON GLP-1 Companion Product Store: https://www.amazon.com/shop/downsized
As an Amazon Associate, I earn from qualifying purchases.

DOWNSIZED LINKS
Https://Thedownsized.Org/ Book The Downsized At Sea Cruise 2026: Https://Thedownsized.Org/Downsized-At...

FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/
+++++++++++++++++++++++++++++++++++++++

00:00 Introduction and Obligatory Disclaimers
00:50 Meet Harith Rajagopalan: CEO of Fractyl Health
01:17 Understanding Obesity and Diabetes
02:38 The Car Analogy: Treating Symptoms vs. Root Causes
07:04 The Role of the Gut in Obesity and Diabetes
13:52 Introducing Reda: A New Procedural Therapy
19:50 Clinical Trials and Promising Results
24:23 Future Prospects and Final Thoughts