Top 5 Peptides for Longevity – Medical Doctor’s Evidence-Based Ranking

Which peptides actually matter for longevity—and which are just hype?
With dozens of peptides circulating online, it’s hard to know which ones truly target the biology of aging. In this video, Dr. Quinn Stillson, MD (functional medicine physician + strength coach) ranks his Top 5 Peptides for Longevity based on mechanistic plausibility, quality of evidence, effect size, and risk–benefit profile.

We break down the real science behind each peptide, how they interact with the hallmarks of aging, and which ones show the strongest potential to improve healthspan—and possibly lifespan. From mitochondrial peptides and senolytics to immune modulators, telomere biology, and GLP-1 agonists, this is a clear, evidence-based ranking—not influencer hype.

💥 If you’re serious about longevity, metabolic health, immune aging, or performance with age, this is the peptide deep dive you’ve been waiting for.

🔬 In this video, you’ll learn:
✅ The criteria used to rank peptides for longevity
✅ Why MOTS-c is called “exercise in a vial” and how it targets mitochondrial dysfunction
✅ How FOXO4-DRI works as a senolytic to clear senescent cells
✅ Why Thymosin Alpha-1 may slow immunosenescence and reduce cancer risk
✅ How Epitalon influences circadian rhythm, telomeres, epigenetics, and lifespan in animals
✅ Why GLP-1 receptor agonists (semaglutide, tirzepatide, retatrutide) currently have the strongest human longevity data
✅ Which peptides act on multiple hallmarks of aging (mitochondria, inflammation, senescence, nutrient sensing, proteostasis)
✅ Where the human data is strong vs where it’s still missing
✅ Who might benefit most from each peptide—metabolic, immune, aging, or performance focused

🎯 Best for:
– Anyone building a longevity or anti-aging strategy
– Clinicians exploring peptide therapy & aging biology
– Individuals with insulin resistance, obesity, or cardiometabolic risk
– Those interested in mitochondrial health, immune aging, or senolytics
– Biohackers who want mechanism + evidence, not hype
– Viewers deciding which peptides are actually worth paying attention to

⏱️ Timestamps:
00:00 What Makes a Top Longevity Peptide? Ranking Criteria
01:51 MOTS-c – Mitochondrial Longevity Peptide (“Exercise Mimetic?” vs SS-31)
03:10 MOTS-c – Lifespan, Healthspan, Muscle & Bone Evidence
05:33 FOXO4-DRI – Senolytic Peptide for Cellular Senescence & Longevity
07:46 FOXO4-DRI – Preclinical Evidence (Testosterone, Senescence Reduction)
09:48 Thymosin Alpha-1 – Immune Modulation & Immunosenescence
12:39 Thymosin Alpha-1 – Cancer & Immune System Evidence
16:24 Thymosin Alpha-1 – Who Might Benefit for Longevity?
17:25 Epitalon – Circadian Rhythm, Melatonin & Telomeres
20:05 Epitalon – Lifespan Extension & Cancer Prevention Data
23:43 GLP-1 Agonists – Semaglutide, Tirzepatide, Retatrutide & Longevity Outcomes
25:31 GLP-1 Agonists – Longevity Benefits Beyond Weight Loss
28:10 GLP-1 Agonists – True Lifespan Extender?

▶️ Related Videos:
MOTS-c Deep Dive →    • MOTS-c (CB-4211): Exercise in a Vial? Full...  
SS-31 Mitochondrial Peptide →    • SS-31 (Elamipretide): FDA-Approved Mitocho...  
TB-4 & TB-500 Explained →    • TB-500 & TB-4: Everything You Need to Know...  
BPC-157 Deep Dive →    • BPC-157: Everything You Need to Know—Benef...  

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⚠️ Medical Disclaimer
This video is for educational purposes only. With the exception of GLP-1 receptor agonists, the peptides discussed are not FDA-approved for human use, and their safety has not been established. All non-approved uses are theoretical and based on preclinical data. Always consult a qualified healthcare professional before starting any medication or peptide.

#Longevity #Peptides #GLP1 #MOTSc #FOXO4DRI #Epitalon #ThymosinAlpha1 #Mitochondria #Senolytics