Slurred Speech in Germ Cell Tumor Encephalitis

Patients with germ cell tumors may develop paraneoplastic encephalitis, and immunoglobulin G autoantibodies to Kelch-like protein 11 (KLHL11) have been identified as a biomarker. This video demonstrates dysarthria in a patient with autoimmune KLHL11 encephalitis, which may also include ataxia, diplopia, nystagmus, hearing loss, tinnitus, and vertigo.

Click
   • Wobbly Gait in Germ Cell Tumor Enceph...   for demonstration of ataxia,
   • Eye Movements in Germ Cell Tumor Ence...   for illustration of nystagmus in the same patient, and https://ja.ma/3hx6aUH for full clinical details from a case series of patients with testicular cancer-related KLHL11 encephalitis.