Lecture On Purine Metabolism: De Novo & Salvage Pathways of Nucleotide Synthesis | MBBS | TSMC

This comprehensive lecture delves into the intricate world of nucleotide metabolism, with a special focus on the synthesis and degradation of purines. This video is an essential resource for medical students, biochemistry students, and anyone with an interest in molecular biology.

Key Topics Covered:

[00:08] Introduction to Purines and Pyrimidines: Learn the fundamental differences in structure and numbering between purines and pyrimidines.
[05:46] Molecular Origins of Purine and Pyrimidine Rings: Discover the specific molecules (glycine, glutamine, aspartate, etc.) that contribute to the formation of these essential rings.
[09:45] Purine Synthesis Pathways:
[10:47] De Novo Synthesis: A detailed, step-by-step explanation of how purines are synthesized from basic precursors, with a focus on the creation of inosine monophosphate (IMP).
[30:53] Salvage Pathway: Understand this energy-efficient alternative for recycling purine bases, and learn about the key enzymes involved, such as APRT and HGPRT.
[37:11] Clinical Correlations and Inhibitors: Explore the medical applications of purine synthesis inhibitors like sulfonamides and methotrexate in treating infections and cancer.
[40:37] Regulation of Purine Synthesis: Learn about the multi-level feedback mechanisms that control the de novo synthesis pathway.
[43:49] From Ribonucleotides to Deoxyribonucleotides: A brief overview of the conversion process essential for DNA synthesis.
[44:51] Purine Degradation: Follow the breakdown of purine nucleotides to their final end product, uric acid.


TRIPURA SANTINIKETAN MEDICAL COLLEGE
Real Class room Demonstration/Lecture On: (BIOCHEMISTRY) METABOLISM OF NUCLEOTIDES)
BY- DR. JASMEET SINGH
(MBBS Batch: 2024- 2025)
Conducted on:- 03-06-25