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Structural and mechanistic insights into PIN8 and its inhibition by Morphactins - Ines Benhammouche
Автор: NanionTechnologies
Загружено: 2025-12-04
Просмотров: 9
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We characterised the auxin transporter PIN8 in complex with the synthetic herbicide Morphactin (Cl-HFC), revealing how it locks the transporter in an outward-occluded state and blocks auxin efflux. Cl-HFC showed higher potency than NPA in SURFE2R-based electrophysiology assays. Structural data uncovered a chlorine-dependent interaction network underpinning Cl-HFC’s specificity and affinity. This unique inhibition mechanism, distinct from phenoxyacetic acid herbicides, provides a basis for developing next-generation, PIN-specific herbicides.
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