Sepsis and Septic Shock

An review of the definitions, presentation, and management of sepsis and septic shock, including fluid and pressor recommendations.

Useful additional resources:

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3): https://jamanetwork.com/journals/jama...

Strong Medicine video on fluid resuscitation:    • IV Fluid Resuscitation (IVF Lesson 3 / Sho...  

Strong Medicine video on pressors:    • Shock: Lesson 5 - Pressors  

An alternative (but compelling) theory on lactic acid production in shock: https://ccforum.biomedcentral.com/art...

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: https://www.ncbi.nlm.nih.gov/pubmed/2... (be aware that there is criticism of this protocol, which has not been replicated in an RCT)