Sonogashira Coupling Reaction| Sonogashira Coupling Reaction Mechanism| With Problems| CSIR-NET GATE

📲🔴Play Store ChemExplore App Link: 👇👇👇👇👇👇
https://play.google.com/store/apps/de...

👇👇👇JUNE-2025 Batch👇👇👇
🔴🔴📖📖Admission Open || 📢📢Register Now || 🎫🎟️Special Discount || Learn from IITan

👇👇👇Complete New Batches👇👇👇
🔴CSIR-NET-JUNE-2025 (Live): https://mksdos.courses.store/509698?u...
🔴CSIR-NET-JUNE-2025 (Recorded): https://mksdos.courses.store/521918?u...
🔴GATE Chemistry-2025 (Live Batch): https://mksdos.courses.store/441256?u...
🔴GATE Chemistry-2025 (Recorded) - Batch: https://mksdos.courses.store/468881?u...
🔴CSIR-NET & GATE Combined-Batch (12-Months): https://mksdos.courses.store/414685?u...
🔴CSIR-NET & GATE Combined-Batch (24-Months): https://mksdos.courses.store/526347?u...
🔴FREE BOOK PDF LINK: 👇👇👇👇👇👇👇👇
https://mksdos.courses.store/434229?u...

In this lecture, we are going to discuss about the Sonogashira cross-coupling reaction. The Sonogashira reaction is a cross-coupling reaction used in organic synthesis to form carbon–carbon bonds. It employs a palladium catalyst as well as copper co-catalyst to form a carbon–carbon bond between a terminal alkyne and an aryl or vinyl halide. This coupling of terminal alkynes with aryl or vinyl halides is performed with a palladium catalyst, a copper(I) cocatalyst, and an amine base. The active Pd(0) catalyst is involved in the oxidative addition step with the aryl or vinyl halide substrate to produce Pd(II) species. Similar to the above discussion, its structure depends on the employed ligands. In the second step oxidative complex reacts with copper acetylide, complex , in a transmetallation step, yielding another complex and regenerating the copper catalyst. For the facile reductive elimination to occur, the substrate motifs need to be in close vicinity, i.e. cis-orientation, so there can be trans-cis isomerisation involved. In reductive elimination the product is expelled from the complex and the active Pd(0) catalytic species is regenerated. The Sonogashira reaction is one of many palladium-catalyzed coupling reactions.
This lecture is very important for upcoming CSIR-NET, GATE, IITJAM, DU, BHU, M.Sc., B.Sc. exams point of view.




(C-C Cross Coupling Reaction Series Part-3)

.......................................................................................................................
Recommendate Link:

Heck Reaction link:    • Heck Reaction|Heck Coupling Reaction Mecha...  

Stille Coupling Reaction link:    • Stille Coupling Reaction|| Stille Coupling...  



.................................................................................................................
#chemexplore #sonogashira_coupling_reaction #organopalladium_chemistry #sonogashira_cross_coupling #sonogashira_reaction_mechanism #chemical_science #sonogashira_coupling_problems_in_csirnet_gate #gate_chemistry_sonogashira_coupling_problem #iitjam #DU #BHU #MSc. #BSc (in Hindi & English)


Thanks for watching my videos. Kindly subscribe to Chem explore and share with your friends.
Keep Sharing, Keep Supporting!!!
Suman Bhowmick


Disclaimer

Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.

The information provided on this channel is a public service with the understanding that Chem Explore CSIR-NET GATE IIT-JAM IIT-JEE makes no warranties, either expressed or implied, related to completeness, accuracy, reliability or suitability of the information. The channel disclaims liability for errors and omissions that may have crept in its content.