Human Blood Groups in Hindi | Human Anatomy and Physiology | Bhushan Science
Автор: Bhushan Science - Nursing
Загружено: 2018-03-04
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RBC membranes bear 30 types of glycoprotein antigens
Anything perceived as foreign; generates an immune response
Promoters of agglutination; called agglutinogens
Mismatched transfused blood perceived as foreign
May be agglutinated and destroyed; can be fatal
Presence or absence of each antigen is used to classify blood cells into different groups
Antigens of ABO and Rh blood groups cause vigorous transfusion reactions
Other blood groups (MNS, Duffy, Kell, and Lewis) usually weak agglutinogens
Types A, B, AB, and O
Based on presence or absence of two agglutinogens (A and B) on surface of RBCs
Blood may contain preformed anti-A or anti-B antibodies (agglutinins)
Act against transfused RBCs with ABO antigens not present on recipient's RBCs
Anti-A or anti-B form in blood at about 2 months of age; adult levels by 8-10
52 named Rh agglutinogens (Rh factors)
C, D, and E are most common
Rh+ indicates presence of D antigen
Anti-Rh antibodies not spontaneously formed in Rh– individuals
Anti-Rh antibodies form if Rh– individual receives Rh+ blood, or Rh– mom carrying Rh+ fetus
Second exposure to Rh+ blood will result in typical transfusion reaction
Also called erythroblastosis fetalis
Only occurs in Rh– mom with Rh+ fetus
Rh– mom exposed to Rh+ blood of fetus during delivery of first baby – baby healthy
Mother synthesizes anti-Rh antibodies
Second pregnancy
Mom's anti-Rh antibodies cross placenta and destroy RBCs of Rh+ baby
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