Breast & Prostate Cancer: How to Lower Your Estrogen Levels | CHEF AJ LIVE! with Peter Rogers, M.D.

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*DISCLAIMER*
This episode in controversial in nature and does not necessarily express the opinions of Chef AJ and the producers of this video.

Dr. Rogers provided all of the research studies that he cited but I am only able to include a few as the YouTube a limit of 5,000 characters.

You tube channel “Dr Anthony Jay.” Phd biochemist, expert on blood lipids, like estrogen, videos about the estrogenic effects of soy.

“Estrogeneration” book by Anthony Jay Phd 2017 cites numerous studies about estrogenic effects of soy, and concerns for possible carcinogenic effects.

Sheehan (2002) “Goitrogenic and estrogenic activity of soy isoflavones” environmental health perspectives, vol 110, June. → A review paper. Says soy has a frenk estrogenic effect in women. Suggests a link between soy consumption and goiter. In rats, genistein is a/w 80% inhibition of enzyme TPO (Thyroid PerOxidase). Soy (genistein) a/w causing uterine adenocarcinoma in adult mice. In one study of women reviewed, soy caused a lengthening of the menstrual cycle (suggests an estrogenic effect). Says human infant soy intake a/w doubling the prevalence of autoimmune disease. Soy a/w problems with TPO in humans, porcine & bovine suggesting it’s a general problem across mammal species.

Kenan (2022) “Developmental exposure to phytoestrogens found in soy: new findings and clinical implications” biochem pharmacol, Jan; 195: 114848. “This indicates that in vivo genistein can have significant biological activity when present in concentrations similar to that of estradiol. In infants consuming soy formulas, plasma isoflavone levels are 13,000-22,000 times HIGHER than plasma estradiol levels, a scenario where genistein is likely to activate estrogen receptor mediated responses.” Recommends warning labels be places on infant soy formula products.

Adgent, Margaret (2018)“Longitudinal study of estrogen responsive tissues and hormone concentrations in [human] infants fed soy formula” j clin endocrinol metab, May 1; 103(5):1899-1909. Those fed soy formula with increased vaginal development, uterine volume and breast development = suggestive of estrogenic effects. Important paper showing DIRECT estrogenic effects in humans.

Allred (2001) “Soy diets containing varying amounts of genistein stimulate growth of estrogen dependent (MCF-7) tumors” cancer res, Jul 1; 61 (13. Soy with increased growth of HUMAN breast cancer cells (MCF-7) in vivo.

Allred (2001) “Dietary genistin stimulates growth of estrogen dependent breast cancer tumors similar to that observed with genistein” carcinogenesis, Oct; 22 (10): 1667. Glycoside genistin, like the aglycone genistein, can stimulate estrogen dependent breast cancer cell growth in vivo. Removal of genistin or genistein from the diet caused tumors to regress.

Zeng (2020) “Effect of soy intervention on insulin like growth factor levels: meta-analysis” phytother res, Jul; 34 (7): 1570-1577. Study showed that soy increased ILGF in humans. (This is of concern, b/c elevated ILGF has been associated with increased risk of diabetes and cancer). I don’t know how much it increased ILGF relative to other foods

Vemuri (2016) “Glycone rich soy isoflavone extracts promote estrogen receptor positive breast cancer cell growth” nutr cancer, May-Jun; 68 (4): 622-33. Says “several recent reports challenged the health benefits of soy isoflavones and associated them with breast cancer promotion.” Soy isoflavones were studied. Conclusion was “our results suggest that the glyconic daidzin rich soy isoflavone extracts may exert estrogenic effects and promote ER+ breast cancer growth.”

Duffy (2007) “Implications of phytoestrogen intake for breast cancer” Sep-Oct; 57 (5):260-277. Says “There is in vivo animal data suggesting the phytoestrogen genistein may interfere with the inhibitive effects of tamoxifen on breast cancer cell growth.”

Velentzis (2008) “Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence?” eur j cancer, Sep; 44 (13): 1799-806. Says “Short term intervention studies suggest a possible stimulatory effect on breast tissue raising concerns of possible adverse effects in breast cancer patients.”