Antibiotics - MCQs - part 8 - pharmacology | antibacterial mcqs

MCQs of pharmacology, antibiotics and antibacterial agents part-8

Antibiotics are agents made from living microorganisms, synthetic manufacturing, and genetic engineering that are used to inhibit specific bacteria. They can be bacteriostatic, bactericidal, or both.

In this video and its affiliated parts in the chemotherapeutic section, multiple-choice questions about antibiotics and antibacterial agents,
about drugs, uses, common side effects, mechanism of action, drug interactions, contraindications, and many important questions that you may encounter in many exams.

Antibiotic class and common indications:
Penicillins: Streptococcal infections (e.g. tonsillitis, pharyngitis, scarlet fever, endocarditis), Sinus infections
Cephalosporins:
1st Gen: Improved activity against gram-positive bacteria and some gram-negative (e.g. E. coli, K. pneumoniae).
2nd Gen: Efficacy against previously mentioned strains as well as H. influenzae, Neisseria spp. – less effective against gram-positive bacteria
3rd Gen: Weak against gram-positive bacteria but potent gram-negative antibiotics.
4th Gen: Improved gram negative and gram-positive coverage compared to
3rd gen, activity against P. aeruginosa and cephalosporin resistant bacteria.
5th Gen: Activity against MRSA, MSSA. Less activity against gram negatives and no pseudomonas coverage.
Tetracyclines: Skin infections, dental infections, atypical infections (Rickettsia spp, Borrelia spp., Chlamydia spp., mycoplasma pneumonia), Adjunct treatment for protozoan infections
Macrolides: Respiratory infections including as an adjunct with a penicillin for pneumonia, STI: Chlamydia, gonorrhea, Otitis media

Vancomycin: Gram-positive infections, Strep, Staph, E. coli, MRSA, Endocarditis, Sepsis/septic shock (empiric coverage), Skin/soft tissue infections, C. diff (when given orally), CNS infections
Sulfonamides: C. trachomatis, Nocardia, H. influenzae, UTIs (e.g. E. coli).

videos links:
MCQs of CNS (Antiepileptics) part-1:
   • Anticonvulsants drugs Antiseizure || MCQs ...  

MCQs of Antibiotics part-1.1:
   • pharmacology mcqs || Antibiotics || part-1...  

NAPLEX pass rate MCQs part-1:
   • mcqs of pharmacology and medicinal chemist...  

#antibiotics #pharmacology #mcq
#antifungal

A Comprehensive Multi-Test Challenge in Pharmacology"

MCQS:

1. Which of the following inhibits DNA gyrase?
A. Penicillin
B. Trimethoprim
C. Chloramphenicol
D. Ciprofloxacin

2. Which of the following is a second generation cephalosporin?
A. Ceftazidime
B. Cephalothin
C. Cefaclor
D. Cefotaxime

3. All of the following are recognised adverse effects of isoniazid EXCEPT
A. Hepatitis
B. Peripheral neuropathy
C. Retrobulbar neuritis
D. ⬇️Phenytoin metabolism →↑ Phenytoin blood levels and toxicity

4. All of the following antibiotics bind to the 505 subunit of the ribosome thereby inhibiting proteinsynthesis EXCEPT
A.  Chloramphenicol
B. Erythromycin
C. Linezolid
D. Doxycycline

5. Resistance to Penicillin and other Beta lactams is due to
A. Modification of target PBPs
B. Presence of an efflux pump
C. Inactivation of antibiotics by ß lactamase
D. All of the above

6. The fluoroquinolones
A. May be administered to patients with severe campylobacter infection
B. Work by inhibiting dihydrofolate reductase
C. Have little effect against gram positive organisms
D. Are heavily metabolised in the liver

7. The cephalosporin with the highest activity against gram positive
cocci is
A. Cefaclor
B. Cephalothin
C. Cefuroxime
D. Cefepime

8. Regarding resistance to antibiotics
A. Penicillinases cannot inactivate cephalosporins
B. Macrolides can be inactivated by transferases
C. Mutation of aminoglycoside binding site is its main mechanism of resistance
D. Tetracycline resistance is a marker for multidrug resistance

9. Concening toxicity of antibiotics
A. Enamel dysplasia is common with aminoglycosides
B. Grey Baby Syndrome occurs with rifampicin use
C. A disulfiram like reaction can occur with macrolides
D. Haemolytic anaemias can occur with sulphonamide use

10. Which of the following is considered to be bacteriostatic?
A. Penicillin
B. Chloramphenicol
C. Ciprofloxacin
D. Tobramycin

11. Half life of amphotericin B is
A. 2 seconds
B. 20 minutes
C. 2 hours
D. 2 weeks

12. Ciprofloxacin
A. Is a defluorinated analogue of nalidixic acid
B. Inhibits tropoisomerases 2 and 3
C. Has bioavailability of 30%
D. Has no gram positive cover

13. Flucloxacillin
A. Is ineffective against streptococci
B. Is active against enterococci and anaerobes
C. Blocks transpeptidation and inhibits peptidoglycan synthesis
D. Is poorly absorbed orally

14. Aminoglycosides
A. Have a ß lactam ring
B. Can produce neuromuscular blockade
C. Are DNA gyrase inhibitors
D. Nomally reach high CSF concentrations

15. Ribosomal resistance occurs with
A. Sulphonamides
B. Penicillin
C. Fluoroquinolones
D. Macrolides

#antibiotics
#pharmacology
#mcq