9 How Trametinib Extends Lifespan by Inhibiting Interleukin 11
Автор: Gamma
Загружено: 2024-08-17
Просмотров: 105
Discover the multifaceted potential of Trametinib in our video! Initially prescribed for melanoma, lung, thyroid, and colon cancers, Trametinib is a kinase inhibitor that blocks enzymes crucial for cell growth. Recent research explores its promising benefits in promoting longevity by targeting aging pathways and reducing chronic inflammation. We'll delve into the MEK/ERK pathway's critical role in cellular functions and how disruptions lead to diseases. Learn about Trametinib's ability to inhibit MEK1 and MEK2, dampening cancer cell growth and inflammation. Plus, find out how Rapamycin, an immunosuppressant, also shows potential in extending lifespan. Don't miss this informative journey into cutting-edge cancer and longevity research!
#Longevity #HealthyAging #Inflammation #Inflammaging #Interleukin11 #trametinib #rapamycin #metformin #MetabolicHealth #AntiAging #Healthspan #Lifespan #ERK #AMPK #mTORC1 #lysosomes #microbiome #Type_2_Diabetes #T2D #fasting #CancerTreatment #LongevityResearch #MEKPathway #KinaseInhibitors #AntiAging #MedicalResearch #ChronicInflammation #CellGrowth
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OUTLINE:
00:00 A Cancer Fighter
01:50 A Cellular Highway
02:51 Inhibiting the Highway
03:51 Side Effects of Trametinib
04:38 A Troublemaker in Cancer and Colitis
05:41 Taming Inflammation and Oxidative Stress
06:43 How Trametinib Fights Cancer
08:27 Exploring Rapamycin's Potential
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This video is based on “Nishina, T., Deguchi, Y., Ohshima, D. et al. Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun 12, 2281 (2021). https://doi.org/10.1038/s41467-021-22450-3”.
Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice.

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