Annonaceous Apprehensions Pt. 2 -- Quantifying Annonacin, Context & Limits of the Guadeloupe Study
Автор: Ockoo Farm
Загружено: 2024-11-01
Просмотров: 1054
NOTE: The annonacin toxicity is probably a separate thing from the alkaloid-based gastrointestinal distress seen when drying the fruit; these are likely separate phenomena.
So I've been on the fence about making this video; invariably the subject rousts some people's dragons, but given the amount of misunderstanding out there I figured it was time to show this. This is how I quantify the annonacin content in pawpaw, and how I view the Guadeloupe Study, a study on Annona muricata leaf tea in the French Guadeloupe (worth also noting -- this is an unconventional use of the plant).
Basic problematic dose is easily googled. As is the quantity in a given fruit. I may be erring on the higher side with annonacin content in pawpaw fruit.
"The Guadeloupe Study" https://pubmed.ncbi.nlm.nih.gov/10440...
Bioavailability of annonacin: https://www.thieme-connect.com/produc...
Suggestion of adjunct toxicity (one example) - https://academic.oup.com/brain/articl...
"About 50% of the atypical patients were not heavy consumers of annonaceaous products, suggesting that other factors, environmental or genetic, might affect the vulnerability of patients to the neurotoxins in Annonaceae."
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