AIRR-C Seminar Series, Feb 27, 2025 - Maria Francesca, École Normale Supérieure, France
Автор: AIRR Community
Загружено: 2025-03-13
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Title: Computational detection of antigen specific B cell receptor for antibody discovery
Early Career Speaker: Maria Francesca, École Normale Supérieure
Talk Abstract
Maria presents her work done during her PhD at the École Normale Supérieure in Paris, in collaboration with Sanofi. It focuses on the development of a computational pipeline to detect specific B cell receptor (BCR) sequences in immunological repertoires. The presentation is divided into two parts: first, the description of the pipeline to identify antigen-specific receptor sequences from a repertoire of sequences and, second, the integration of this tool into a complete antibody discovery process.
Speaker Bio
Maria Francesca Abbate is a computational immunologist with a background in statistical physics, specialized in B-cell receptor repertoire analysis and antibody discovery. During her PhD at the École Normale Supérieure de Paris, in collaboration with Sanofi, she developed computational methods to identify antigen-specific B-cell receptors, integrating statistical modeling and experimental validation. Her work contributed to a complete antibody discovery pipeline, leading to the identification of potential therapeutic candidates targeting the GFRAL receptor, involved in appetite regulation.
AIRR-C Seminar Series website: https://www.antibodysociety.org/the-a...
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