Oral Wegovy (GLP-1): Dosing, Switching, and What to Expect

Oral Wegovy is here, and people have a lot of questions. In this Docs Who Lift episode, Dr. Spencer Nadolsky and Dr. Carl Nadolsky break down how oral semaglutide is formulated to survive the stomach, why the pill uses a special absorption helper, and why the dose numbers look so different compared to injections.

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We also talk through real world dosing and switching. If you are moving from injectable Wegovy or Ozempic to oral Wegovy, we explain the logic behind conservative vs aggressive transitions, what we are doing in clinic so far, and the practical rules that matter most for absorption, including timing, water amount, and the empty stomach requirement. We also cover how this can get tricky if you take thyroid medication and why consistency matters more than perfection.

Finally, we dig into what happens when people stop GLP 1s using SURMOUNT 4 post hoc data. You will hear the real spread of outcomes, who maintains, who regains, and why weight regain is so individualized. If you are thinking about switching to oral Wegovy or you are planning for maintenance long term, this episode will help you make a more informed plan with your clinician.

This podcast is for education and entertainment only and is not personal medical advice. Always talk with your clinician about your specific situation.

00:00 Intro to Oral Wegovy and GLP-1 Pills
01:00 What Oral Wegovy Is and How It Works
03:30 Oral vs Injectable GLP-1 Differences
06:30 Dosing and Titration Basics
09:30 Switching From Wegovy or Zepbound to Oral Wegovy
12:30 Tolerability and Side Effects Considerations
15:00 How and When to Take Oral Wegovy
18:00 Cost, Access, and Real-World Use
20:30 Weight Regain and Maintenance Data
23:00 Who May or May Not Stay on GLP-1 Long Term
24:30 Final Takeaways and Practical Advice