EC50, ED50, Potency & Efficacy Explained | Dose–Response Curves Made Simple for Pharmacology

In this video, we break down EC50, ED50, EMAC (maximal effect), potency, and efficacy using clear dose–response curve explanations designed for medical and pharmacology students. Understanding these fundamentals is essential for exams such as the ANZCA Primary, USMLE, NCLEX, and university pharmacology modules.

You’ll learn how the effective dose 50 (ED50) and effective concentration 50 (EC50) reflect a drug’s potency, why left-shifted curves indicate higher potency, and how to recognise decreased potency when the curve shifts to the right. We also explain how the maximal effect (Emax) defines efficacy, and how full agonists differ from partial agonists based on their ability to reach 100% response.

This video is perfect if you’re revising pharmacodynamics, studying receptor behaviour, or trying to simplify complicated exam topics.

📌 In this video, you’ll learn:

What EC50 and ED50 actually measure

How potency relates to the ED50

Why left-shifted curves indicate higher potency

The meaning of Emax (EMAC) and maximal effect

Full agonists vs partial agonists

Why partial agonists can’t reach 100% efficacy

How to interpret dose–response graphs for exams

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