Lipoprotein(a): A Neglected Risk Factor or a Clinical Imperative? - Grand Rounds HHS

Speaker: Dr. Khaled Hossameldin Ahmed

Objectives:

1. Lp(a) Demystified:
Understand the structure, genetic regulation, and biological role of lipoprotein(a) in lipid metabolism.

2. A Subclinical Risk Factor?:
Review current evidence linking elevated Lp(a) levels with increased cardiovascular risk, independent of other lipids.

3. Defining the Danger Zone:
Identify clinically significant Lp(a) thresholds associated with heightened atherosclerotic and thrombotic risk.

4. Impact on Cardiovascular Outcomes:
Explore how elevated Lp(a) contributes to residual cardiovascular risk and adverse clinical outcomes.

5. Clinical Integration of Lp(a):
Learn how Lp(a) levels are being used to inform risk stratification and guide treatment decisions in practice.

6. Who Should Be Screened?:
Discuss current recommendations and criteria for Lp(a) testing in various patient populations.

7. Challenges in Lp(a) Quantification:
Examine the limitations in assay variability, standardization, and result interpretation in clinical settings.

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McMaster University’s, Department of Medicine Grand Rounds (MGR), combined with Hamilton Health Sciences and St. Joseph’s Healthcare Hamilton, is held on rotation every Thursday via ‘Teams’ and uploaded to our channel weekly.

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We acknowledge with gratitude and respect that McMaster University, Hamilton Health Sciences, and St. Joseph’s Healthcare Hamilton, stand on the traditional territory shared between the Haudenosaunee confederacy and the Anishinabe nations, recognized in the Dish with One Spoon Wampum belt treaty.