What Is Thalassemia & How It Affects The Body? | GFGV

Thalassemia is an inherited blood disorder where the body makes abnormal or less hemoglobin than normal, a protein in red blood cells essential for carrying oxygen.

This leads to fewer healthy red blood cells and can cause anemia, resulting in fatigue, weakness, and pale skin, with severity ranging from mild (trait) to severe, potentially requiring lifelong treatments like blood trxnsfusions / removal & replacement for severe forms.

It's classified as alpha or beta thalassemia, depending on which globin chain gene is affected, and is common in people of Mediterranean, South Asian, and Southeast Asian descent.

How it works.

Normal Hemoglobin.

Composed of alpha and beta globin chains.

Thalassemia.

A genetic defect causes reduced or absent production of one of these chains.

Result.

Red blood cells don't form properly, are destroyed too quickly, and can't carry enough oxygen.

Types of Thalassemia.

Alpha Thalassemia.

Affects the alpha-globin gene; severity depends on the number of missing genes (1-4).

Beta Thalassemia.

Affects the beta-globin gene; can range from minor (trait) to major (Cooley's Anemia).

In essence, the most severe forms of both are life-threatening, but they manifest differently.

Alpha-thalassemia often ends life prenatally or at birth, while severe Beta- thalassemia is a chronic, lifelong condition that requires intensive management to sustain life.

This video comes off the back of the sickle cell production, uploaded to the channel.

With the thought in mind to bring awareness and give those who need, but may not know where to look for this type of crucial information, easy access and knowledge, compiled in one place.

HAPPY NAVIGATION. GOOD LUCK.


What Is Thalassemia & How It Affects The Body? | GFGV


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