Concise Synthesis of Isosteroidal Alkaloids with Michael Zott and Daniel Zuschlag
Автор: Synthesis Workshop Videos
Загружено: 2025-06-20
Просмотров: 1138
In this Research Spotlight episode, Michael Zott and Daniel Zuschlag join us to share their work on the synthesis of isosteroidal alkaloids.
Key reference:
J. Am. Chem. Soc. 2025, 147, 3010-3016.
https://doi.org/10.1021/jacs.4c16495
Additional references (in order of appearance):
Phytochem. Rev. 2014, 13, 671–694.
Veratramine’s effects on ion channels: Journal of Pharmacology and Experimental Therapeutics 1973, 184 (1), 143
Planta Med. 1992, 58, 449–453.
J. Nat. Prod. 1998, 61, 1078–1081.
Smith’s paspaline synthesis: J. Am. Chem. Soc. 1989, 111, 5761–5768
Enone formation: Bull. Chem. Soc. Jpn. 2000, 29, 1072–1073
Oxidant preparation: Chem. Sci., 2018, 9, 5389–5393
Thermal Eschenmoser Fragmentation: Helv. Chim. Acta 1972, 55, 1276–1319.
Piperidine desaturation: Adv. Synth. Catal. 2014, 356, 119–124. a12% additional material gained through isomerization.
Unselective crotylation: J. Org. Chem. 2012, 77, 4235–4241.
GreenCat: Tetrahedron 2013, 69, 7408–7415.
Nickel conditions: Tetrahedron 1998, 54, 1255. Rhodium conditions: J. Am. Chem. Soc. 1990, 112, 4965.
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