LET IT RIP: Jacoby Brissett, Arizona Cardinals Need to Air It Out to Beat San Francisco 49ers

The Arizona Cardinals enter a critical Week 11 matchup against the San Francisco 49ers with significant implications for evaluating their young core, despite Marvin Harrison Jr.'s absence due to recovering from an appendectomy.

Host Alex Clancy delivers an in-depth breakdown of why this game represents the Cardinals' best remaining opportunity for victory this season, particularly with the 49ers missing defensive anchors Nick Bosa and Fred Warner. The episode challenges Arizona's conservative offensive philosophy, arguing that quarterback Jacoby Brissett must attempt 35-45 passes to exploit San Francisco's depleted secondary and linebacker corps.

Central to the game plan is maximizing Trey McBride, who's enjoying a historic season for a Cardinals tight end and could deliver a career-defining performance. Clancy examines how Michael Wilson's underrated route-running and contested catch ability position him as the primary perimeter threat, while Greg Dortch's versatility in the slot and gadget plays offers creative solutions to generate explosive plays.

Defensively, the episode emphasizes one non-negotiable priority: containing Christian McCaffrey. Clancy analyzes how the Cardinals must commit extra defenders to stopping the run, forcing Brock Purdy into obvious passing situations where Arizona's pass rush can generate pressure and create turnover opportunities—the statistical key to their upset chances.

Beyond X's and O's, the discussion explores why this game matters more for talent evaluation than draft positioning. With Paris Johnson Jr. anchoring the offensive line, Garrett Williams emerging in the secondary, and Buddha Baker providing veteran leadership, Clancy identifies the foundational pieces Arizona is building around. The offensive line's recent struggles receive scrutiny, particularly in pass protection, as does the coaching staff's tendency toward overly conservative play-calling that limits the offense's ceiling.

The episode also addresses the broader context of Arizona's season trajectory, examining which young players are proving themselves as long-term building blocks versus those who may not factor into future plans. Clancy provides specific predictions for key player performances, discusses situational football scenarios that could determine the outcome, and explains why an aggressive, pass-heavy approach gives the Cardinals their best chance to compete against a wounded but still dangerous division rival.

Whether you're evaluating Arizona's rebuild progress or seeking tactical insights into this NFC West clash, this episode offers comprehensive analysis of the Cardinals' most winnable remaining game and what it reveals about their path forward beyond 2025. Let's discuss.


The Best Daily Arizona Cardinals Podcast. Host Alex Clancy (@ClancysCorner) take an unbiased approach covering the biggest Cards stories.

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