USMLE Genetics High Yield Rating for Step 1

Expect about 16 genetics questions on the exam

Correction: I said & wrote "Post-Translational Mods" when I really meant post-TRANSCRIPTIONAL modifications. Thanks to Sean Typher for point out the typo in the comments!

10 – Autosomal Recessive Inheritance
9 – X Linked Recessive Inheritance
9 – Pedigrees
7 – Post-transcriptional Modification
6 – Translation
6 – Trinucleotide Repeat Expansion
5 – Mitochondrial Inheritance
5 – Tuberous Sclerosis
4 – Epigenetics
4 – Autosomal Dominant Inheritance
4 – Lesch Nyhan
3 - DNA Replication
3 – Imprinting, Angleman & Prader-Willi
3 – Polygenic Inheritance
3 – Neurofibromatosis
3 – Down Syndrome
2 – Variable Expressivity
2 – Variable Expressivity
2- Mosaicism
2 – Pleiotropy
2 – Incomplete Penetrance
2 – Von Hippel Lindau

No Yield:
• Nucleotide & DNA/RNA Structure
• Ligase, Telomerase, Helicase, Primase ….
• Okazaki Fragments & the process of transcription
• DNA Repair Mechanisms & Related Diseases
• Gene Regulation
• Specifics about Protein Synthesis
• Meiosis & Mitosis
• X-Linked Dominant
• Hardy-Weinberg Calculations
• Uniparental disomy
• Locus heterogeneity
• Pyrimidine Synthesis
• Purine Synthesis
• Orotic Aciduria
• Sturge Weber Syndrome
• Osler-Weber-Rendu Syndrome
• Ataxia Telangiectasia
• Cri du Chat
• Edwards
• Patau
• Friedrichs Ataxia
• Myotonic dystrophy