New Genetic Cause for Microcephaly: EXOSC10 Gene Discovery

microcephaly genetics EXOSC10 gene RNA degradation Sonic hedgehog brain development neural stem cells primary microcephaly
Dive into the groundbreaking research from Ruhr University Bochum uncovering a novel genetic cause of microcephaly. Learn how mutations in the EXOSC10 gene disrupt RNA degradation and lead to excessive Sonic hedgehog signaling, causing smaller brain size and developmental issues.
This video explores the study's findings, including mouse model experiments that mimic human conditions and reveal how stem cell balance is crucial for brain growth. Discover the implications for understanding neurodevelopmental disorders and the role of advanced sequencing technologies.
Key topics covered:
What is microcephaly and its impacts
Role of EXOSC10 in RNA metabolism
How Sonic hedgehog signaling affects cortical development
Insights from Dr. Tran Tuoc and the research team
Potential avenues for future research in genetic brain malformations
Perfect for anyone interested in genetics, neuroscience, and medical breakthroughs.