Cubane in Drugs?

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Corrections: There were some errors in a few of the slides, corrected slides can be found at https://docs.google.com/presentation/...

Cubane is a molecule that has fascinated chemists due to its unique structure. In this video we go through the discovery, synthesis and applications of cubane in medicinal chemistry and drug design.

Sources:

General-
https://pubs.acs.org/doi/10.1021/acs....
https://pubs.acs.org/doi/10.1021/acs....
Eaton papers-
https://pubs.acs.org/doi/10.1021/ja01...
https://onlinelibrary.wiley.com/doi/e...
Escape from Flatland-
https://pubs.acs.org/doi/10.1021/jm90...
Opioid antagonists-
[https://doi.org/10.1016/0968-0896(95)...](https://doi.org/10.1016/0968-0896(95)...)
Validating Eaton’s Hypothesis-
http://dx.doi.org/10.1002/anie.201510675
Macmillan-
https://chemrxiv.org/engage/chemrxiv/...
Attribution
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