Antimicrobial Resistance and Horizontal Gene Transfer | Microbiology

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► THIS VIDEO will provide valuable insights into the critical issue of antimicrobial resistance, especially for medical students. It highlights how resistance to antimicrobial compounds rapidly emerges, leaving us with fewer options to treat bacterial infections 🦠The video explains various mechanisms of antimicrobial resistance, such as enzymatic breakdown, chemical modification, and genetic changes, using examples like vancomycin and β-lactam antibiotics 💊 It also discusses the concerning spread of resistance genes among bacteria through plasmids and other means, emphasizing the urgency of addressing this global healthcare challenge. 🔬🧫

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► THE PROF 📚🏫
Your lecturer is Prof. Dr. Vincent Racaniello. He is teaching microbiology and immunology at Columbia University in New York City. He is a leading expert in the research of viruses and human diseases. Therefore Racaniello has served on the editorial boards of scientific journals, such as the Journal of Virology or PLOS Pathogens. Furthermore he was the 2015 president of the American Society for Virology. Beyond that he is editor of an online virology blog and co-producer of the podcasts Netcast This Week in Virology, This Week in Parasitism and This Week in Microbiology. 🩺

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Chapters:
00:00 Introduction to Antimicrobial Resistance
01:04 Mechanisms of Antimicrobial Resistance
01:15 Enzymatic Breakdown
01:21 Chemical Modification
01:25 Inhibition of Uptake
01:32 Stimulation of Export
01:39 Target Site Modification
01:55 Case Study: Vancomycin Resistance
03:28 β-Lactam Antibiotics and Resistance
04:02 The Widespread Problem of Plasmid-Mediated Resistance
05:51 Horizontal Gene Transfer
06:00 Common Mechanisms of Resistance