EP. 207 | Tirzepatide + Metabolic Health: What the Latest Study Really Shows | Solo

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A new study on tirzepatide just dropped, and some obesity experts claim it confirms that the drug works only by reducing calories. After reading the full paper myself, I’ve got a different take. In this episode, I unpack what the study actually shows—like how tirzepatide increases fat oxidation without impacting metabolic adaptation—and why the “calories in, calories out” story doesn’t tell the whole truth. There’s more going on here, and you deserve the full picture.
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On This Episode We Cover:

00:00:00 – Introduction
00:02:44 – Obesity study on GLP1s and weight loss
00:04:21 – Calories in vs. calories out
00:05:44 – Resting metabolic rate
00:09:25 – Metabolic adaptation during dieting
00:12:11 – Tirzepatide dosing in clinical studies
00:15:49 – Maintaining weight loss
00:18:15 – GLP1s & increased fat oxidation
00:19:14 – GLP1 microdosing myths
00:26:06 – Metabolic rate drops vs. metabolic improvements
00:29:51 – Lessons from the Biggest Loser study
00:34:20 – Study Comparation
00:35:25 – Weight loss, inflammation, and aging
00:36:35 – Health autonomy
00:40:23 – Caloric restriction and the CALERIE study
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Studies Mentioned:

Tirzepatide Did Not Impact Metabolic Adaptation In People With Obesity, But Increased Fat Oxidation https://pubmed.ncbi.nlm.nih.gov/40203...
Persistent Metabolic Adaptation 6 Years After The Biggest Loser Competition https://pmc.ncbi.nlm.nih.gov/articles...
Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) https://www.nia.nih.gov/research/reso...
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Show Links

GLP-1s Done Right University https://www.drtyna.com/offers/VstUywX...
Dr. Tyna’s Strength Corner https://www.drtyna.com/offers/jyTRpoF...
Metabolic Revamp Toolkit + Masterclass https://www.drtyna.com/offers/FYvv4hJ...

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Further Listening:

GLP1s Uncovered (Free Class) https://bit.ly/GLP1uncovered
   • EP. 202 | The Fight for Affordable GLP1s &...  
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Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.
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