Dr Gerwin Puppels – Skin models vs in vivo skin: insights from Raman spectroscopy
Автор: LE STUDIUM Loire Valley IAS
Загружено: 2024-07-12
Просмотров: 116
Dr Gerwin Puppels (RiverD international B.V.) – NL
Skin models play an important role in the transition to animal free testing. However, just as animal skin is not the same as human skin, skin models are not human skin, even if they look much the same under a microscope. One of the important functions of the skin is barrier formation; to keep water in and to keep the outside world … out. That process starts immediately after birth. In vivo Raman spectroscopy offers a clear, non-invasive window on this barrier development.
The presentation will summarize the information about the skins’ molecular composition and molecular anatomy, barrier formation and skin penetration, that can be obtained by in vivo Raman spectroscopy.
It will then make the comparison between in vivo skin and various skin models with respect to these aspects. Raman spectroscopy could serve as a great, perhaps sometimes confronting, tool to further guide and test the development of skin models towards becoming real life-like skin models, in appearance, but also in terms of molecular composition and skin physiological and functional aspects.
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