Gene Therapy for Osteoarthritis: Exciting Possibilities or Dangerous Risks?

In this conversation, Oscar Tellez and Professor Ali Mobasheri delve into the complexities of regenerative medicine, particularly focusing on stem cells and their applications in treating osteoarthritis. They discuss the evolution of stem cell therapy, the importance of understanding biological age, and the nuances of processing and variability in treatments. The conversation also highlights the role of secretomes and extracellular vesicles, the challenges of gene therapy, and the regulatory landscape that impacts innovation in the field. Ultimately, they emphasize the need for collaboration and open dialogue in advancing medical treatments.

Takeaways

Stem cells have not delivered the promised cures for osteoarthritis.
Understanding the biological age of stem cells is crucial.
Real-world applications of therapies often differ from clinical trial results.
The secretome may offer a safer and more effective treatment option.
Gene therapy presents both exciting possibilities and significant risks.
Regulatory frameworks are essential for ensuring patient safety.
Mistakes in research are valuable learning opportunities.
Collaboration across disciplines can lead to innovative solutions.
Economic factors play a significant role in treatment adoption.
Patient education on treatment options is vital for informed decisions.

Chapters

00:00 Introduction to Regenerative Medicine and Osteoarthritis Research
02:24 The Evolution of Stem Cell Therapy
05:54 Nuances in Stem Cell Applications
10:48 Understanding Autologous vs Allogenic Stem Cells
15:21 Biological Age vs Chronological Age of Stem Cells
20:54 The Importance of Evidence in Stem Cell Research
25:33 Challenges in Regenerative Medicine and Patient Expectations
30:37 The Role of Extracellular Vesicles in Therapy
35:45 Regulatory Perspectives on Stem Cell Treatments
39:56 Patient Demographics and Treatment Outcomes
46:16 Healthcare Systems and Economic Disparities
49:03 The Role of Live vs. Dead Cells in Regeneration
53:59 Innovations in Stem Cell Therapies
01:00:04 The Promise of Secretomes and Exosomes
01:06:19 Navigating Regulatory Challenges in Stem Cell Therapy
01:11:43 Future Directions in Gene Therapy
01:19:00 Global Perspectives on Stem Cell Regulations

Professor Ali Mobasheri:
LinkedIn Profile:   / ali-mobasheri-68009712  

Oscar Tellez:
LinkedIn Profile:   / o-tellez  
Regenerative Medicine Academy Website: https://regenmedacademy.com
Regenerative Medicine Marketing: https://regenportal.com
Regenerative Medicine Products: https://accretionportal.com

Disclaimer:
The information provided in this video is for educational and informational purposes only and is not intended as medical, legal, or financial advice. Always consult with a qualified healthcare provider, legal professional, or financial advisor for guidance specific to your situation.
The views expressed are those of the speaker and do not represent medical diagnosis, treatment, or business guarantees. Participation in this video or live session does not establish a provider–patient relationship or a business advisory agreement.
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