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Andrew Allen, Gritstone Oncology on Cancer Neoantigen Vaccines
Автор: PMWCintl
Загружено: 2019-01-28
Просмотров: 2935
Описание:
Neoantigens arise from somatic mutations that differ from normal cell antigens and are specific to each individual patient – providing tumor specific targets for developing personalized cancer vaccines. Current clinical trials using neoantigen targeting cancer vaccines, including in combination with checkpoint blockade monoclonal antibodies, have demonstrated potent T-cell responses against those neoantigens accompanied by tumor regression in patients. Personalized neoantigen vaccines represent one of the most significant advances in the history of cancer treatment.
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