Rewiring the Brain: How Ketamine Infusion Therapy Sparks Hope – Dr. Geoff O’Neill

What if healing could begin in weeks, not years?
Dr. Jeff O’Neal, founder of Ketamine Uplift and practicing anesthesiologist, joins Robb Pollard to explain how low-dose ketamine therapy triggers neuroplasticity —the brain’s ability to rewire itself—and how he’s watched people go from hopeless to smiling within two weeks.

They walk through the science, the misconceptions, and the practical side of recovery—from addiction and depression to finding peace after hitting rock bottom.

⏱️ Timestamps

00:00 “When we talk about rock bottom…” — hope returns in 2 weeks
00:45 Meet Dr. Jeff O’Neal of Ketamine Uplift in Marina del Rey
01:15 How he became an anesthesiologist and discovered ketamine’s potential
03:00 From surgery rooms to mental-health recovery
04:20 What ketamine actually does — neuroplasticity explained
06:40 The science & studies behind low-dose infusions
08:55 How it reprograms thought patterns and mood
10:30 Why ketamine differs from antidepressants and SSRIs
12:10 Intention + medicine = lasting change
14:40 Why most patients find it as a last resort — and why that must change
16:00 The stigma vs. the truth: club drug to life-saving therapy
17:00 The transformations he sees every week
18:15 “Is this how normal people feel again?” — lifting the fog
19:45 Robb’s journey from addiction to clarity
23:00 Common misconceptions and safety facts
26:00 Where ketamine therapy is heading next 5 years
27:30 What a session actually feels like
33:00 Let go and trust the process — why intention matters
34:30 Resilience and the will to seek help
35:30 Message to anyone at rock bottom — you’re not alone
37:00 Walk With Me, Brother becomes a nonprofit and its mission to fund therapy access

💡 Key Themes

How ketamine creates neuroplasticity and rewires thought patterns

The difference between suppression and healing

Addiction recovery and intentional mental-health treatment

Misconceptions and stigma around psychedelic medicine

The future of mental health and accessible care

Walk With Me Brother’s mission to help men who can’t afford therapy

🔗 Connect & Follow

Dr. Jeff O’Neal
• Instagram: @ketamineuplift

• Website: https://www.ketamineuplift.com

Walk With Me, Brother Podcast
• Instagram: @walkwithmebrother

Host – Robb Pollard
• Instagram: @itsrobbp

• Website: https://www.walkwithmebrother.com

Resources:
National Suicide Prevention Lifeline: 988
Crisis Text Line: Text HOME to 741741

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