Protein misfolding at the centre of Alzheimer’s disease │ Professor Louise Serpell

Abstract:
Protein misfolding is central to many diseases including Alzheimer's disease. However, the mechanism by which conformational change is initiated remains elusive. Alzheimer's disease is characterised by key proteins including Tau, Amyloid-beta and by the risk factor isoform Apolipoprotein E4. However, the role of each of these in the neurodegenerative disease cascade is unclear. Our work aims to explore the initiation events that lead to misfolding and the downstream effects on neuronal function, whilst clarifying the potentially toxic species. In this talk, I will describe work that aims to uncover fundamental mechanisms at the heart of the structural changes in Amyloid-beta, tau and ApoE4.

Speaker:
Professor Louise Serpell is a Professor of Biochemistry at the University of Sussex, UK and a Director of Sussex Neuroscience. Her work focusses on protein self-assembly and misfolding at the heart of neurodegenerative diseases and amyloidosis. Louise started her work on amyloid fibril structure during her PhD at the University of Oxford, UK before moving to the University of Toronto, Canada to focus on Alzheimer’s disease at the Centre for Neurodegenerative Diseases. She returned to the UK to the Laboratory of Molecular Biology, MRC Centre in Cambridge and then took up a fellowship at the University of Cambridge. She has worked in Sussex for over 16 years. Her current work spans structural biology to cellular neuroscience to uncover the mechanisms that lead to neurodegeneration in ageing diseases.

Moderator:
Mahmoud Maina, PhD. University of Sussex, UK.
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Coordinator:
Mosab Ali Awadelkareem, Al-Neelain University, Sudan.

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