Migraine - Pharmacology

In this video, we dive deep into the Pharmacology of Migraine, exploring the complex pathophysiology and the various drug classes used to manage this neurological condition. Whether you’re a medical student preparing for exams like USMLE/MBBS or a healthcare enthusiast, this video simplifies the mechanisms behind Triptans, Ergots, and the latest CGRP-targeting therapies.
​📚 Key Concepts Covered
​Pathophysiology: Learn about Cortical Spreading Depression (CSD) and the activation of the trigeminal nerve.
​Acute Treatment: Why we use 5-HT_{1B/1D} agonists (Triptans) to induce vasoconstriction and inhibit pro-inflammatory peptide release.
​Prophylaxis: Understanding the use of Propranolol, Amitriptyline, and Topiramate in reducing attack frequency.
​Recent Advances: A breakdown of Erenumab (CGRP receptor antagonist) and Rimegepant (Gepants).


​⚠️ Medical Disclaimer:
​This video is for educational purposes only and does not constitute medical advice. Always consult with your doctor or a qualified healthcare provider before starting or stopping any medication. If you are experiencing a medical emergency, call your local emergency services immediately.


Notes drive link:https://drive.google.com/file/d/1RZQZ...


Time Stamps:


00:40 Severe Migraine
01:14 Drugs for Migraine
03:45 Triptans
06:19 Prophylaxis of Migraine