the extracellular matrix (& aging)

Today we are going to talk about the components that appears in many aging papers, yet always appears to be lurking in the background with it being acknowledged, but largely ignored. that is the extracellular matrix. now, the extracellular matrix, being the substance outside of cells, is also somewhat lurking in the background, but today i will put it centre stage and describe the cool and complex ways in which it contributes to our biology, and take some discussion to how the extracellular matrix changes with age.


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References:
Swahari, V., Nakamura, A., Hollville, E. et al. miR-29 is an important driver of aging-related phenotypes. Commun Biol 7, 1055 (2024). https://doi.org/10.1038/s42003-024-06...
Teuscher, A.C., Statzer, C., Goyala, A. et al. Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans. Nat Commun 15, 276 (2024). https://doi.org/10.1038/s41467-023-44...
Dynamic duo: Cell–extracellular matrix interactions in hair follicle development and regeneration - https://doi.org/10.1016/j.ydbio.2024....

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at RIKEN. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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