Treat feline infectious peritonitis (FIP) with pills, not injections

Audience: veterinary surgeons, veterinary students and nurses.
Relapses are more likely to occur if you begin treating feline infectious peritonitis (FIP) with injections, rather than pills. Feline coronavirus, the virus that causes FIP, replicates in the intestines: first in the epithelium of the tips of the villi of the small intestine, and later in the ileum and colon. Pills get right to where the virus replicates in the intestines, stopping the virus dead in its tracks, whereas injectable antivirals, such as GS-441524 or remdesivir, do not enter the gut well, so cats can still shed coronavirus in their faeces, even though they may appear to have recovered from FIP. Antiviral injections may appear to heal feline infectious peritonitis temporarily, but they predispose to a relapse, especially a neurological relapse if too low a dose of antiviral has permitted virus to persist in the brain.
Key messages:
1. do NOT use injections to treat FIP: use pills.
2. start treatment with a high dose of antiviral (exact dose will depend upon what you're using).

To download the 10 Rules to Prevent FIP relapses, or to make a donation to support films like this one, please visit my website: www.catvirus.com.

Antiviral drug resistance video:    • Resistance to antivirals  

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Link to Dr Addie’s FIP treatment paper: www.mdpi.com/1999-4915/14/4/744
Link to Dr Pedersen’s GS-441524 paper: https://journals.sagepub.com/doi/10.1...
Link to Dr Roy’s molnupiravir paper: www.mdpi.com/2076-0817/11/10/1209

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