The Binding of Isaac | Today's Daily Run 21st Jan 2026

Goal: Isaac vs. Satan [Normal Difficulty]
Spiciest Stuff: Rotten Tomato, Dark Bum, Death's Touch, Pentagram, Aquarius (w/Headless Baby – double trail!), The Halo

It's Isaac's second run of the month/year, but his first non-curated.

I must have missed something here... I can't recall such a dire set of items in a long run like this with the D6 in hand. DMG and Tear Rate are both mid at best. Rotten Tomato's infighting was very welcome, especially when it hit a few enemies at once with the scythes.

Skipped a decent chunk of the prior floors and was STILL too slow to make it to Boss Rush... The Mom fight took ages!

It gave enough time to get to Hush easily at least (still skipped a lot of rooms however).
A Magician card really helped out here, always a treat to use with Aquarius.

Health was often quite low at times, although not too worrisome overall as it gets topped up by Dark Bum.
Didn't find any defensive items to speak of.

I was hoping to bounce back after yesterday's defeat but this one wasn't it.

Best of luck!

Fun rating: ⭐⭐

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