Unit 1 Medicinal Chemistry 5th Semester |Oneshot | Antihistaminic Agents | Antiantineoplastic Agents

Unit 1 Medicinal Chemistry 5th Semester | Oneshot | Antihistaminic Agents | Antiantineoplastic Agents

📝 Syllabus Covered (As per PCI):
🔸 Antihistaminic Agents
  • Histamine – receptors and their distribution in the human body

H1-Antagonists:
  • Diphenhydramine hydrochloride*
  • Dimenhydrinate
  • Doxylamine succinate
  • Clemastine fumarate
  • Diphenylpyraline hydrochloride
  • Tripelenamine hydrochloride
  • Chlorcyclizine hydrochloride
  • Meclizine hydrochloride
  • Buclizine hydrochloride
  • Chlorpheniramine maleate
  • Triprolidine hydrochloride*
  • Phenindamine tartrate
  • Promethazine hydrochloride*
  • Trimeprazine tartrate
  • Cyproheptadine hydrochloride
  • Azatadine maleate
  • Astemizole
  • Loratadine
  • Cetirizine
  • Levocetirizine
  • Cromolyn sodium

H2-Antagonists:
  • Cimetidine*
  • Famotidine
  • Ranitidine

Gastric Proton Pump Inhibitors (PPIs):
  • Omeprazole
  • Lansoprazole
  • Rabeprazole
  • Pantoprazole

🔸 Antineoplastic Agents

Alkylating Agents:
  • Mechlorethamine*
  • Cyclophosphamide
  • Melphalan
  • Chlorambucil
  • Busulfan
  • Thiotepa

Antimetabolites:
  • Mercaptopurine*
  • Thioguanine
  • Fluorouracil
  • Floxuridine
  • Cytarabine
  • Methotrexate*
  • Azathioprine

Antibiotics:
  • Dactinomycin
  • Daunorubicin
  • Doxorubicin
  • Bleomycin

Plant Products:
  • Etoposide
  • Vinblastine sulphate
  • Vincristine sulphate

Miscellaneous:
  • Cisplatin
  • Mitotane


⏱️ Chapters & Time Stamps:
00:00 – Introduction
01:35 – Important Questions
03:38 – Antihistaminic Agents
12:01 - Biosynthesis, Storage, Release and Catabolism of Histamin
25:08 - Some Physiological role of Histamine
28:08 - Histamine Receptor [H1, H2, H3, H4] Receptor
38:23 - Classification of Antihistamines
44:54 - SAR of Antihistamines
55:34 - H1 Antagonists (first generation, second generation) MOA,
01:01:00 - Diphenhydramine Hydrochloride
01:09:22 - Promethazine Hydrochloride
01:16:50 - H2 Antagonists
01:26:55 - Cimetidine
01:33:48 - SAR of H2 Antihistamines
01:38:26 - Gastric Proton Pump Inhibitors
01:40:36 - MOA (Proton pump inhibitors)
01:42:51 - Omeprazole
01:45:18 - Antineoplastic Agents, Cancer
02:00:23 - Types and Causes of Cancer
02:05:52 - Classification of Anti-Neoplastic Agents
02:07:58 - Alkylating Agents
02:19:45 - Mechlorethamine (Mustin)
02:24:17 - Anti-Metabolites
02:32:30 - Mercaptopurine, Methotrexole
02:39:04 - Antibiotics (MOA)


🔗 Related & Recommended Videos:

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