SARS-CoV-2 Structure (COVID-19 Coronavirus)

A structural exploration of the proteins produced by SARS-CoV-2.

PDB FILES:
6VSB - Spike protein
6VW1 - RBD of the spike protein in complex with ACE2
6SGC - Rabbit ribosome stalled on a poly-A tail
6Y2E - SARS CoV-2 main protease
6Y2F - SARS CoV-2 main protease bound to an inhibitor

REFERENCES:
• Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C. L., Abiona, O., ... & McLellan, J. S. (2020). Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science, 367(6483), 1260-1263.
• White, J. M., Delos, S. E., Brecher, M., & Schornberg, K. (2008). Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Critical reviews in biochemistry and molecular biology, 43(3), 189-219.
• Zhang, L., Lin, D., Sun, X., Curth, U., Drosten, C., Sauerhering, L., ... & Hilgenfeld, R. (2020). Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science.
• Fehr, A. R., & Perlman, S. (2015). Coronaviruses: an overview of their replication and pathogenesis. In Coronaviruses (pp. 1-23). Humana Press, New York, NY.