Logan Collins | Viruses Inside Vaults: A Powerful New Gene Therapy Delivery System

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Logan Collins | Viruses Inside Vaults: A Powerful New Gene Therapy Delivery System
Logan Thrasher Collins is a synthetic biologist, author, and futurist. He is currently a PhD candidate in biomedical engineering at Washington University in St. Louis. Logan began engaging in scientific research during his sophomore year of high school when he created a new synthetic biology approach for combatting antibiotic resistant infections. Since then, he has led research projects on developing x-ray microscopy techniques for connectomics, using molecular dynamics simulations to study SARS-CoV-2, and inventing novel gene therapy delivery systems. Logan has spoken at TEDxMileHigh and has published peer-reviewed scientific papers on his research. He has also published science fiction and sci-fi poetry and as well as a peer-reviewed philosophy journal article. Logan passionately advocates for applying interdisciplinary solutions to global challenges and leverages both the arts and sciences to help build a bright future.
https://logancollinsblog.com/

Timecodes
00:00 Introduction and Welcome
00:37 Overview of Gene Therapy Research
01:42 Challenges with AAV Gene Therapy
05:37 Innovative Solutions: Protein Vaults
07:21 Mechanism of Protein Vaults
15:30 Experimental Results and Findings
24:36 Future Directions and In Vivo Studies
29:56 Developing In Vitro Experiments for Gene Editing
30:05 Challenges in Gene Expression and Aging Treatments
30:48 CRISPR and Gene Editing Plans
31:27 Illustration of Cas9 and Homology Directed Repair
32:20 Targeting Specific Cell Types with Volt AAVs
33:27 Forming Cathedral Therapeutics and Seeking Funding
34:26 Q&A Session
47:05 Final Questions and Collaboration Opportunities
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