🩺 Human Immunodeficiency Virus (HIV) in Adults Objective 2 | When to Choose What 💊✅
Автор: Alireza FakhriRavari, PharmD, BCPS, BCIDP, AAHIVP
Загружено: 2025-10-23
Просмотров: 61
🎯 Learning Objective 2: Given a treatment-naïve HIV-1 patient, recommend DHHS guideline-concordant antiretroviral therapy.
Turn guidelines into clean, defensible picks. Build a fast algorithm for treatment-naïve HIV-1 using patient-specific factors (HBV coinfection, renal function, pregnancy potential, cardiovascular risk, HLA-B*57:01, OIs, DDIs):
Go-to anchors: INSTI-based regimens (e.g., bictegravir/TAF/FTC, or dolutegravir + TAF/FTC or TDF/FTC) 🧱
HBV coinfection: pick TAF/FTC or TDF/FTC in the backbone 🧬
Renal/bone/CV nuances: TAF vs TDF considerations 🦴💙
When to avoid/modify: abacavir concerns, boosted PI niches, two-drug options in select settings
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