Hypertension Pathophysiology| Renal, RAAS, SNS, Vascular Remodeling | Applied Pharmacology(Part 2)

In this video, we cover Hypertension – Part 2, focusing on the complete pathophysiology of systemic hypertension with clear applied clinical and pharmacological correlations.
This lecture explains how blood pressure is regulated and how long-term alterations in:
Renal sodium handling & pressure-natriuresis
RAAS activation
Sympathetic nervous system overactivity
Vascular remodeling and arterial stiffness
Genetic & monogenic causes
lead to chronic hypertension, target-organ damage, and guide rational antihypertensive drug selection.

🔹 Ideal for MBBS, MD, DM, nursing exams, and clinicians wanting conceptual clarity.
------------------------------------------
Timestamps;
00:00 Intro
00:46 Determinants of Blood pressure
04:18 Role of (1)Intravascular volume and Renal sodium handling
04:24 Pressure-Natriuresis mechanism and it's alteration in HTN
05:58 Effect of Chronic high salt intake and body's response(autoregulation)
08:56 Applied aspect and drugs
11:20 Role of (2) Renin-Angiotensin-Aldosterone system(RAAS)
15:53 Reason for stopping ACEi and ARBs temporarily in volume loss states
17:06 Applied aspect and drugs
21:54 Role of (3) Autonomic Nervous system and Sympathetic hyperactivity
22:56 Role of baroreceptors in HTN
25:00 Role of alpha-1 and 2 receptors
27:02 image explaination of (3)
29:15 Applied aspect and drugs
30:15 (4) Vascular remodeling and Arteial stiffness
32:08 Role of small arteries(resistance vessels)
34:00 Role of Large arteries(Conduit vessels) and loss of windkessel effect
36:51 Applied aspect and drugs
37:00 Role of (5) Genetics and epigenetics
38:04 Monogenic HTN
38:37 Liddles syndrome

#Hypertension
#HypertensionPathophysiology
#BloodPressureRegulation
#RAAS
#PressureNatriuresis
#RenalPhysiology
#SympatheticNervousSystem
#VascularRemodeling
#ArterialStiffness
#AntihypertensiveDrugs
#LiddlesSyndrome
#MedicineLectures
#Cardiology
#Nephrology
#MBBS
#MDMedicine