6 Progressive Multiple Sclerosis Theories

00:36 innate immune injury
3:09 meningeal b-cell follicles
4:49 mitochondrial failure
7:01 Oxidative injury
8:09 EBV
10:17 normal aging

Some people with MS have progressive symptoms despite stable MRI scans. But why? This video explains 6 theories as to why this occurs and potential treatments.

Selected Sources:

PET scans (18F-PBR06-PET), people with MS on highly effective disease modifying therapy still have innate immune activation: https://pubmed.ncbi.nlm.nih.gov/38630...
Is multiple sclerosis a mitochondrial disease?: https://www.ncbi.nlm.nih.gov/pmc/arti...
Harding’s disease: an important MS mimic: https://www.ncbi.nlm.nih.gov/pmc/arti...
Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration: https://pubmed.ncbi.nlm.nih.gov/29132...
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain: https://www.ncbi.nlm.nih.gov/pmc/arti....



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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.