2025 ELN Recommendations on the Management of CML
Автор: International CML Foundation
Загружено: 2025-07-20
Просмотров: 1532
Professor Jane Apperley
Imperial College, London (UK)
The European LeukemiaNet (ELN) has issued expert consensus recommendations for managing CML since 2006, with updates in 2009, 2013, and 2020. The 2025 version, recently accepted for publication in Leukemia, reflects evolving clinical data, new therapies, and a growing emphasis on individualised care.
The full publication can be accessed here: https://www.nature.com/articles/s4137...
00:40 ELN recommendations: process
04:14 Defining disease phase in CML - including new WHO criteria for defining disease phase in CML
10:58 Prognosis at diagnosis - including impact of ASXL1 mutation at diagnosis
17:43 Monitoring response to treatment
19:08 Response milestones 2025 - including 'Why personalise the milestones?'
31:32 First-line treatment - including first-line treatment with asciminib
36:20 Resistance
38:14 Treatment-free remission
39:22 Parenting - including pregnancy outcomes and planning a pregnancy in established CML
42:33- Adverse events
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