FIRST TAKE | 49ers are NFL's best team vs 6 Pro Bowlers - Stephen A. on Brock Purdy sink Colts 48-27

GET UP | Brock Purdy is UNREAL - Jeff Saturday on 49ers QB throw 5 TD to sink Colts 48-27 Week 16

The Prince makes the climb, Josh Allen drops, Who will reach the top of Mahomes Mountain? | FTF

San Francisco 49ers offense on fire ahead of pivotal stretch | Pro Football Talk | NFL on NBC

"Brock Purdy is too GOOD"- Pat McAfee reacts to Brock Purdy’s 5-TD powers 49ers past Colts 48-27

FIRST TAKE | Ravens should TRADE Lamar Jackson if they miss the Playoffs - Mad Dog tells Stephen A.

NFL LIVE | CMC & George Kittle is Best Offensibe Duo in NFL - Swagu on 49ers def. Colts 48-27

Brock Purdy was EXCEPTIONAL throwing 5 TDs, Is John Harbaugh on the hot seat for the Ravens? | FTF

San Francisco 49ers vs Indianapolis Colts Game Highlights | 2025 NFL Season Week 16

FIRST TAKE | Jerry Jones goes bankrupt with his silly deals - Stephen A. RIPS Cowboys are eliminated

"BROCK PURDY IS A GAME CHANGER!" - Acho and Shady BREAK DOWN Purdy's 5 TD performance

GMFB | 49ers are going to win NFC - Kyle Brandt on Brock Purdy 5 TDs to beat Colts 48-27 Week 16

Will the 49ers be the No. 1 SEED in NFC ⁉️ 'I think so' - Jeff Saturday 👀 | Get Up

Week 17 Preview: Chicago Bears vs. San Francisco 49ers | Chris Simms Unbuttoned | NFL on NBC

NFL LIVE | Marcus Spears reacts to Brock Purdy fires 5-TD, 295-Yds lead 49ers defeat Colts 48-27

FIRST TAKE | NFL should fear Eagles as Hurts playoff mode - Stephen A. on Philly back-to-back win

GMFB | "Shanahan unlocked MVP Purdy form" - Kyle Brandt on Brock gets 5-TDs lead 49ers rout Colts

Brock Purdy is going to Super Bowl! - Emmanuel Acho tells Shady on 49ers dominate Colts 48-27 on MNF

Cam Newton reacts to DK Metcalf's fan interaction: 'We need to bolster the protection' | First Take

49ers vs. Colts Reaction 🍿 Purdy throws 5 TDs as San Fran eyes 1 seed | SC with SVP

San Francisco 49ers - Indianapolis Colts Highlights - KNBR Audio - 12/22/25 - @ Lucas Oil Stadium