Protein, IGF-1 and Health Q&A - with Valter Longo, PhD | The Proof Podcast EP 238

In Episode 238, Dr Valter Longo returns to clarify some specific questions that arose from last week’s episode on protein.

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Last week’s conversation, Episode 237, was a deep dive of protein, longevity, and cancer with Valter Longo, PhD, as part of The Proof’s extended exploration of protein. We examined IGF-1 and mTOR, looking towards the impact of protein consumption on our long-term health. Today, Dr Longo ties off some loose ends on this nuanced conversation, clarifying his stance and providing guidance.

Dr Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the USC Leonard David School of Gerontology, one of the leading centres for research on aging and age-related disease. Dr Longo is also the Director of the Longevity and Cancer Program at the IFOM Institute of Molecular Oncology in Milan, Italy. His studies focus on the fundamental mechanisms of aging in simple organisms and mice, and on how these mechanisms can be translated to humans.

In this episode, I ask Dr Longo clear questions extending on last week’s episode. We discuss biological age testing, amino acid deficiency, and how to measure cancer risk. We also cover the consequences of high IGF-1, Laron syndrome, and longevity, and whether exercising neutralises the risk of protein consumption.

Specifically, we discuss:

0:00 Intro
1:47 Reduce Cancer Risk with IGF1
4:11 Biological Age Test
6:24 Laron Syndrome & Longevity
13:06 Does Everyone with High IGF1 get cancer?
20:30 Pressure for Longevity
22:15 Does Exercise Reduce Risk?
26:19 Average IGF1
31:03 Conclusion

It was great to have Valter Longo, PhD back on the show to clarify some questions that remained after last week’s episode. Stay tuned for an upcoming episode summarising and evaluating The Proof’s recent dialogue on protein.
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Make sure to listen to the last episode of The Proof: https://theproof.com/protein-fasting-... where Dr Valter Longo and I examine protein consumption in detail.

Connect with Dr Valter Longo:
• Instagram:   / prof_valterlongo  
• Facebook:   / profvalterlongo  
• Website: https://www.valterlongo.com/
• His Book, The Longevity Diet: https://www.valterlongo.com/the-longe...
• Dr Longo first appeared on The Proof in Episode 106, which you can listen to here: https://theproof.com/slow-ageing-figh...

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Enjoy, friends.

Simon

Supporting studies

• Exercise, Dietary Protein, and Combined Effect on IGF-1 • [PMID: 33564731] https://pubmed.ncbi.nlm.nih.gov/33564731
• IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome • [PMID: 28528685] https://pubmed.ncbi.nlm.nih.gov/28528...

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