Pregabalin vs Gabapentin – Kaunsi Better Hai? Don’t Take the Wrong Nerve Pain Medicine!

Pregabalin vs Gabapentin – Nerve Pain Treatment Explained | Dr Amod Manocha, Pain Specialist
👉 Many patients ask: “Which one should I take – pregabalin or gabapentin?”
In this video I break down the differences between these two widely-used gabapentinoids: their mechanisms, similarities, key differences, evidence from clinical studies, common mistakes, and practical guidance so *you* can make a smarter choice (in consultation with your doctor) and hopefully gain better comfort and result.

🧠 What you’ll learn:
• How gabapentinoids work (why they take time, what to expect)
• What pregabalin & gabapentin share (indications, side-effects, kidney considerations)
• The critical differences: absorption/bioavailability, onset speed, potency, dosing flexibility, cost/regulation
• Key clinical evidence: meta-analyses, head-to-head trials (2022-24)
• Real-world-practical guidance: when I personally prefer one over the other
• Common mistakes I see in my pain-clinic (under-dosing, stopping early, mis-matching patient profile)
• Safety, monitoring & precautions you must know — especially for older patients, kidney function, sedatives, driving/balance issues

⏱ Key sections
What are gabapentinoids / How they work
Similarities between pregabalin & gabapentin
Key Differences – absorption, potency, onset, cost
Evidence & Clinical Studies (meta-analyses, head-to-head)
Common Mistakes & Myths
Which one suits whom?
Safety, Monitoring & Precautions
Recap & Key Takeaways

StatPearls — Pregabalin (Pharmacokinetics & safety summary). https://www.ncbi.nlm.nih.gov/books/NB...
LiverTox / NIH — Gabapentin & Pregabalin hepatotoxicity summary (2020). https://www.ncbi.nlm.nih.gov/books/NB...
Systematic review on gabapentinoid effectiveness & safety (sciatica/neuropathic pain reviews 2021) https://pmc.ncbi.nlm.nih.gov/articles...

🎯 Who should watch this?
This video is ideal if you or someone you care for is taking or considering *nerve-type pain medicines* (for sciatica, diabetic neuropathy, post-herpetic neuralgia, chronic spinal nerve pain) and you want clear, evidence-based guidance—not hype.

📌 Why this topic matters
Choosing the “right” gabapentinoid isn’t just or “cheap vs expensive” — the mechanism, patient profile (kidney function, age, comorbidities), dosing flexibility and clinical evidence all matter. A sub-optimal choice or under-trial can mean months of extra discomfort. My goal is to clear the confusion so you can decide with confidence.

🔍 Don’t forget:
• This is **information only**.
• Always *consult your physician or pain-specialist* before making changes to medications.
• If you’re already on one of these drugs, *don’t stop or switch* without medical supervision

For more information & help:
📍 : International Pain Centre (IPC)
A-10, Neeti Bagh, New Delhi – 110049
📞 +91-9993336525
🌐 internationalpaincentre.com | removemypain.com

📲 Stay Connected for More Updates:
✅ Subscribe on YouTube – @DrAmodManocha
✅ Instagram –   / internationalpaincentre  
✅ Facebook – https://www.facebook.com/profile.php?...

🙏 Support the Channel
👍 Like the video
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📤 Share with anyone using or considering using these medicines

About the Doctor: He is currently working at the International Pain Centre (https://internationalpaincentre.com), Delhi as the Head of Pain Management Services. He is trained as a Pain Management Specialist and an Anaesthetist in the UK. He has over 13 years of work experience in the UK including working as a Chronic Pain Consultant in many UK hospitals. Dr. Manocha believes in a multidisciplinary approach and providing evidence-based treatments at par with international standards. He is committed to providing quality care and believes in building a long-term relationship with patients based on honest communication and keeping their interests foremost.

Disclaimer: All information in this video is provided in good faith for general informational purposes only and is aimed at empowering patients with adequate knowledge about the condition being discussed. It is NOT intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified healthcare provider. Do not disregard professional medical advice or delay seeking medical treatment because of any information in this video. We give no warranty of any kind regarding the accuracy, adequacy, reliability, validity or completeness of any information. Your reliance on any information in the video is solely at your own risk. We shall not have any liability, under any circumstances, for any losses or damages incurred as a result of the information in this video.

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