COMT Gene: Symptoms, Diet, and Supplement Tips

Could your genes be making it harder to manage stress, focus, or get restful sleep? In this video, I break down the COMT gene—a key player in how your body handles dopamine, adrenaline, and stress.

🧬Genetic Testing packages: https://2ly.link/261YY
🧪 Mental Health Lab Testing: https://2ly.link/261YZ

🎥 This video was edited by:
Rahul Kanchi   / rahul-kanchi  

🚑 If you are in a mental health crisis, please dial 9-8-8 from the U.S. Or text HOME to 741741 and connect to a crisis counselor.
You can find a list of international crisis lines here: https://blog.opencounseling.com/suici...

References:
Dušanka Mitrović, Snežana Smederevac, Delgado-Cruzata, L., Selka Sadiković, Dejan Pajić, Prinz, M., Zoran Budimlija, Oljača, M., Jelena Kušić-Tišma, Nataša Vučinić, & Aleksandra Milutinović. (2024). Personality and COMT gene: molecular-genetic and epigenetic associations with NEO-PI-R personality domains and facets in monozygotic twins. Frontiers in Genetics, 15. https://doi.org/10.3389/fgene.2024.14...

Funke, B., Malhotra, A. K., Finn, C. T., Plocik, A. M., Lake, S. L., Lencz, T., DeRosse, P., Kane, J. M., & Kucherlapati, R. (2005). COMT genetic variation confers risk for psychotic and affective disorders: a case control study. Behavioral and brain functions : BBF, 1, 19. https://doi.org/10.1186/1744-9081-1-19

González-Castro, T. B., Tovilla-Zárate, C., Juárez-Rojop, I., Pool García, S., Genis, A., Nicolini, H., & López Narváez, L. (2013). Distribution of the Val108/158Met polymorphism of the COMT gene in a healthy Mexican population. Gene, 526(2), 454–458. https://doi.org/10.1016/j.gene.2013.0...

Millenet, S. K., Nees, F., Heintz, S., Bach, C., Frank, J., Vollstädt-Klein, S., Bokde, A., Bromberg, U., Büchel, C., Quinlan, E. B., Desrivières, S., Fröhner, J., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lemaire, H., Martinot, J. L., … Hohmann, S. (2018). COMT Val158Met Polymorphism and Social Impairment Interactively Affect Attention-Deficit Hyperactivity Symptoms in Healthy Adolescents. Frontiers in genetics, 9, 284. https://doi.org/10.3389/fgene.2018.00284

Norrholm, S. D., Jovanovic, T., Smith, A. K., Binder, E., Klengel, T., Conneely, K., Mercer, K. B., Davis, J. S., Kerley, K., Winkler, J., Gillespie, C. F., Bradley, B., & Ressler, K. J. (2013). Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder. Frontiers in behavioral neuroscience, 7, 30. https://doi.org/10.3389/fnbeh.2013.00030

Olasunkanmi, O. I., Aremu, J., Wong, M. L., Licinio, J., & Zheng, P. (2024). Maternal gut-microbiota impacts the influence of intrauterine environmental stressors on the modulation of human cognitive development and behavior. Journal of Psychiatric Research, 180, 307–326. https://doi.org/10.1016/j.jpsychires....

Pelgrim, T. A. D., Ramaekers, J. G., Wall, M. B., Freeman, T. P., & Bossong, M. G. (2023). Acute effects of Δ9-tetrahydrocannabinol (THC) on resting state connectivity networks and impact of COMT genotype: A multi-site pharmacological fMRI study. Drug and Alcohol Dependence, 251, 110925. https://doi.org/10.1016/j.drugalcdep....

Knickmeyer, R. C., Wang, J., Zhu, H., Geng, X., Woolson, S., Hamer, R. M., ... & Gilmore, J. H. (2014). Common variants in psychiatric risk genes predict brain structure at birth. Cerebral Cortex, 24(5), 1230–1246. https://doi.org/10.1093/cercor/bhs401

Sinclair, J. (2022, November 28). COMT Gene Mutation: Symptoms, Treatment and Diet. YouTube.    • COMT GENE Mutations, Symptoms & Treat...  
Wang, L., Chen, Y., Wang, M., Zhao, C., & Qiao, D. (2023). Relationship between gene-environment interaction and obsessive-compulsive disorder: A systematic review. Journal of Psychiatric Research, 164, 281–290. https://doi.org/10.1016/j.jpsychires....

Wang, L. J., Lee, S. Y., Chen, S. L., Chang, Y. H., Chen, P. S., Huang, S. Y., Tzeng, N. S., Chen, K. C., Lee, I. H., Wang, T. Y., Yang, Y. K., & Lu, R. B. (2015). A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder. Scientific reports, 5, 8813. https://doi.org/10.1038/srep08813

Disclaimer: All of the information on this channel is for educational purposes only and not intended to be specific/personal medical advice or substitute for diagnosis and treatment of any conditions discussed herein. Furthermore, watching these videos or getting answers to comments/questions, does not establish a provider-patient relationship. Please consult with your own healthcare provider for proper diagnosis and treatment.

Note: This video is not sponsored. Some of the links provided are affiliate links, meaning I may earn a small commission from purchases made through those links.