Perspective on Clinical Pharmacology & Pharmacometric Aspects of CAR-T & TCR-T Cellular Therapies

Webinar presented on April 22, 2022

With the promise of potentially “single dose curative” paradigm, CAR-T therapies have brought a paradigm shift in the treatment and management of oncology indications specially in hematologic malignancies, and the field is rapidly evolving. For hematologic malignancies US FDA approved CAR-Ts now extend beyond CD-19 targeting CAR-Ts to also include the recently approved BCMA targeting CAR-T. Rapid advancements in the field now include “off-the shelf” allogenic CAR-T therapies in clinical development that overcome the long and difficult wait time seen with autologous CAR-T therapies for cancer patients. There are unique clinical pharmacology, pharmacometric, & biopharmaceutic aspects of development of CAR-Ts that offer challenges yet great opportunity for optimization of development for this important class of ex-vivo gene therapy. This webinar will highlight some of these aspects including characterization of CAR-T dose-exposure-response relationships for efficacy & safety & factors affecting these relationships, FIH dose selection & optimal clinical study design considerations as well as unique aspects of development of TCR-T therapies that offer great potential for solid tumor indications.

IQ Consortium
Translational & ADME Sciences Leadership Group
New Modalities Working Group

Learn more at iqconsortium.org