服用华法林期间饮食上的注意事项有哪些 孟泳 河南省中医院

服用华法林期间饮食上的注意事项有哪些 孟泳 河南省中医院
服用华法林期间饮食上要注意哪些呢，第一刚才说过许多饮食跟华法林之间，要么增加华法林抗凝作用，要么减弱华法林抗凝作用，比如绿色蔬菜，包括菠菜、卷心菜、芦笋、西芹，芥蓝、豌豆等等，这些富含维生素K的绿色蔬菜，它会减弱华法林的抗凝效果。那么这时候呢，我们就会把根据国际化标准比值，适当增加华法林的量，增加抗凝效果，有些食物它可增强华法林的抗凝效果，比如大蒜与华法林合用时候，可增加华法林抗凝作用，比如鱼油可通过抑制血小板聚集，降低与凝血相关血栓素，或者维生素K依赖性凝血因子的水平，它反而增加了华法林的抗凝作用，葡萄柚含有香豆素类化合物，同时可抑制肝脏有关药物代谢酶的活性，减少华法林的代谢，相应的就在增加了华法林的抗凝作用，芒果与华法林合用，也可以增强它的抗凝作用，所以这些食物与华法林在一起使用的时候，注意一定要减少华法林的用量。

What are the dietary precautions when taking warfarin
What should we pay attention to when taking warfarin, First of all, I just said that there is a lot between food and warfarin, Either increase the anticoagulant effect of warfarin, The anticoagulant effect of warfarin can be weakened, For example, green vegetables, Including spinach, cabbage, asparagus, celery, Mustard, peas, etc, These green vegetables are rich in vitamin K, It will weaken the anticoagulant effect of warfarin. So at this time, We will set the ratio according to the international standard, Increase the amount of warfarin appropriately, Increase anticoagulant effect, Some foods can enhance the anticoagulant effect of warfarin, For example, when garlic and warfarin are used together, It can increase the anticoagulant effect of warfarin, For example, fish oil can inhibit platelet aggregation, Reduce thromboxane associated with coagulation, Or vitamin K-dependent clotting factor levels, On the contrary, it increases the anticoagulant effect of warfarin, Grapefruit contains coumarins, At the same time, it can inhibit the activity of liver related drug metabolism enzymes, Reduce the metabolism of warfarin, Accordingly, the anticoagulant effect of warfarin is increased, Mango and warfarin are used together, It can also enhance its anticoagulant effect, So when these foods are used with warfarin, Be sure to reduce the use of warfarin.