Memorize 4 Uses of Rituximab Mnemonic

Rituximab is a monoclonal antibody (mAb) that targets the CD20 antigen; it depletes B cells and is used as a therapeutic biologic agent in rheumatoid arthritis (RA), as well as other autoimmune disorders and lymphoproliferative disorders.

Among interventions for RA, rituximab is considered a biologic disease-modifying antirheumatic drug (DMARD) because it can decrease the signs and symptoms of disease and reduce the progression of joint injury. The activation of the immune system induced by rituximab to deplete B cells, together with its immunogenicity and immunosuppressive properties, are largely responsible for its adverse effects, including infusion reactions, reduced immunoglobulin levels, and increased risk of certain infections. .

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